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KMID : 0043320150380040494
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Archives of Pharmacal Research
2015 Volume.38 No. 4 p.494 ~ p.504
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Anti-inflammatory activity of betalain-rich dye of Beta vulgaris: effect on edema, leukocyte recruitment, superoxide anion and cytokine production
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Martinez Renata M.
Longhi Balbinot Daniela T.
Zarpelon Ana C.
Staurengo Ferrari Larissa
Baracat Marcela M.
Georgetti Sandra R.
Sassonia Rogerio C.
Jr. Waldiceu A. Verri
Casagrande Rubia
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Abstract
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We have recently developed betalain-rich beetroot (Beta vulgaris) dye (betalain) to be used in food products. Betalain (30?300 mg/kg) intraperitoneal (i.p.) treatment diminished carrageenan (100 μg/paw)-induced paw edema and neutrophil migration to the paw skin tissue. Betalain (100 mg/kg) treatment by subcutaneous or per oral routes also inhibited the carrageenan-induced paw edema. Importantly, the post-treatment with betalain (100 mg/kg, i.p.) significantly inhibited carrageenan- and complete Freund’s adjuvant (10 μl/paw)-induced paw edema. Betalain (100 mg/kg) also reduced carrageenan (500 μg/cavity)-induced recruitment of total leukocytes, including mononuclear cells and neutrophils, as well as increasing vascular permeability in the peritoneal cavity. Furthermore, betalain significantly reduced carrageenan-induced superoxide anion, tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-1β levels in the peritoneal fluid, as well as augmenting IL-10 levels. Therefore, this compound presents prominent anti-inflammatory effect on carrageenan-induced paw edema and peritonitis by reducing the production of superoxide anion and the cytokines TNF-α and IL-1β, in addition to increasing IL-10 levels. These results suggest that betalain shows therapeutic potential that could be utilized in the treatment of inflammation-associated diseases.
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KEYWORD
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Beta vulgaris, Betalain, Acute inflammation, Paw edema, Cytokines, Superoxide anion
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